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Title : "I believe this is the first time this has happened in the history of cancer."
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"I believe this is the first time this has happened in the history of cancer."

Said Dr. Luis A. Diaz Jr., of Memorial Sloan Kettering Cancer Center, quoted in "A Cancer Trial’s Unexpected Result: Remission in Every Patient/The study was small, and experts say it needs to be replicated. But for 18 people with rectal cancer, the outcome led to 'happy tears'" (NYT).

The inspiration for the rectal cancer study came from a clinical trial Dr. Diaz led in 2017 that Merck, the drugmaker, funded... [T]he cancers all shared a gene mutation that prevented cells from repairing damage to DNA.... Patients in that trial took a Merck checkpoint inhibitor, pembrolizumab, for up to two years.... That led Dr. Cercek and Dr. Diaz to ask: What would happen if the drug were used much earlier in the course of disease, before the cancer had a chance to spread?... 

Dr. Diaz began asking companies that made checkpoint inhibitors if they would sponsor a small trial. They turned him down, saying the trial was too risky. He and Dr. Cercek wanted to give the drug to patients who could be cured with standard treatments. What the researchers were proposing might end up allowing the cancers to grow beyond the point where they could be cured. 

“It is very hard to alter the standard of care,” Dr. Diaz said. “The whole standard-of-care machinery wants to do the surgery.” 

Finally, a small biotechnology firm, Tesaro, agreed to sponsor the study. Tesaro was bought by GlaxoSmithKline, and Dr. Diaz said he had to remind the larger company that they were doing the study — company executives had all but forgotten about the small trial....

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